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Additional file 11 of Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species

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posted on 2025-02-04, 04:35 authored by Montserrat Torres-Oliva, Elisa Buchberger, Alexandra D. Buffry, Maike Kittelmann, Genoveva Guerrero, Lauren Sumner-Rooney, Pedro Gaspar, Georg C. Bullinger, Javier Figueras Jimenez, Fernando Casares, Saad Arif, Nico Posnien, Maria D. S. Nunes, Alistair P. McGregor, Isabel Almudi
Additional file 11: Fig. S6. Effects of loss and gain of otd expression in ommatidial structure and facet size in D. melanogaster. Loss of otd causes defects in ommatidia structure. (a-c) Knockdown of otd by expressing UAS-miR-otd with GMR-GAL4 driver in D. melanogaster eye. (a-a’) GMR-GAL. (b-b’) GMR-GAL/ UAS-miR-otd shows a rough eye phenotype due to defects in ommatidia arrangements. (c-c’) GMR-GAL/ UAS-miR-otd phenotype is rescued by co-expressing UAS-otd. (d-d’) otd imutant mitotic clones also show defects in ommatidia size and organisation. (e) Comparison of facet area from eyes of UAS-otd (“+, otd”), ato3’FL-GAL4 (“ato>+) and UAS-otd; ato3’FL-GAL4 (“ato>otd”) female adults. Facet area is significantly larger in the experimental genotype (“ato>otd”) than in the two control genotypes. See main text for details.

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Deutsche Forschungsgemeinschaft Biotechnology and Biological Sciences Research Council Ministerio de Ciencia, Innovación y Universidades European Research Council

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