12936_2021_3979_MOESM11_ESM.pdf (358 kB)
Additional file 11 of Analysis of pir gene expression across the Plasmodium life cycle
journal contribution
posted on 2021-11-26, 05:15 authored by Timothy S. Little, Deirdre A. Cunningham, Audrey Vandomme, Carlos Talavera Lopez, Sarah Amis, Christopher Alder, John W. G. Addy, Sarah McLaughlin, Caroline Hosking, George Christophides, Adam J. Reid, Jean LanghorneAdditional file 11: Fig. S4. A Transcriptional deconvolution of each sample from every time point using scRNAseq data [14].
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francis crick institute imperial college london wellcome trust The Francis Crick Institute
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red blood cellsincluding antigenic variationdistinct expression patternspir gene transcriptspir gene expressionmale gametocytes producelargest multigene familydetermine function experimentallystudied plasmodium speciesdifferent pir genesplasmodium speciespir genesresults expressionproduce relativelyfemale gametocytesdifferent timesplasmodium chabaudipir proteinssuggest rolesrepetitive naturepotential tractabilitynotably comparedmarked exceptionliver merozoiteslife cyclelarge numberinvestigation dueimportant roleimmune evasionhighly transcribedhigh resolutionfuture experimentsfunctional investigationfunctional distinctionsdirect evidencechronic infection
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