40170_2015_133_MOESM10_ESM.pdf (596.81 kB)
Additional file 10: Figure S5. of Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation
journal contribution
posted on 2015-08-26, 05:00 authored by M. Brahimi-Horn, Sandy Giuliano, Estelle Saland, Sandra Lacas-Gervais, Tatiana Sheiko, Joffrey Pelletier, Isabelle Bourget, Frédéric Bost, Chloé Féral, Etienne Boulter, Michel Tauc, Mircea Ivan, Barbara Garmy-Susini, Alexandra Popa, Bernard Mari, Jean-Emmanuel Sarry, William Craigen, Jacques Pouysségur, Nathalie MazureGlutathione peroxidase expression and the effect of ebselen. (A) Immunofluorescence to GPX7 in Wt and Vdac1 −/− MEF in Nx or Hx for 72 h. (B) Immunoblotting for HIF-1α of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia. (C) Proliferation of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia. (D) Viability of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia.