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MOESM9 of STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers

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posted on 17.10.2019, 04:59 by Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho, Chun-Chia Cheng
Additional file 9: Figure S1. BBI608 is a potential therapeutic agent against lung cancers. A panel kit containing 172 compounds was used to search for therapies effective against EGFR-positive HCC827, A549, H1975, and EGFR-negative H520 cell lines. The effective agents were selected based on a cell viability level lower than 40%. Among the therapies, only BBI608 markedly reduced cell viability against HCC827, A549, and H1975 rather than H520 cells. (TIF 2396 kb)

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Ministry of Science and Technology, Taiwan

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