12885_2019_6217_MOESM11_ESM.tif (912.68 kB)

MOESM11 of STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers

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posted on 17.10.2019, 04:58 by Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho, Chun-Chia Cheng
Additional file 11: Figure S3. There were 55 reduction genes among BBI608 (BBI)-, YM155 (YM)-, shSTAT3, and shG9a-treated A549 cells (Additional file 6: Table S6), which were subsequently analyzed using NetworkAnalyst. (A) The 55 genes were classified using PANTHER ( http://www.pantherdb.org/ ) based on molecular functions. The genes were listed based on their molecular functions, including binding (24 genes), catalytic activity (16 genes), molecular function regulator (5 genes), molecular transducer activity (3 genes), structural molecule activity (1 gene), transcription regulator activity (2 genes), and transporter activity. (B) NetworkAnalyst revealed that the ERBB signaling pathway was the major inhibitory pathway, particularly reducing ERBB3 expression. (C) STAT3-G9a-regulated genes were compared with miR-145-5p-targeted genes from TargetScan resulted in four overlapping genes, including PLA2G4A, MTUS1, ERBB3, and TSKU. (TIF 912 kb)

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