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Additional file 7 of STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

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posted on 2021-01-15, 04:27 authored by Yahui Zheng, Chong Huang, Lu Lu, Kangkang Yu, Jing Zhao, Mingquan Chen, Lu Liu, Qingfeng Sun, Zhifei Lin, Jianming Zheng, Jinhong Chen, Jubo Zhang
Additional file 7: Figure S5. Inhibition of mitophagy suppresses HCC migration and sensitizes HCC cells to Lenvatinib treatment. (A–B) SMMC-7721 and HCCLM3 control and derived cells were co-treated with LV (5μM) and CQ (5μM) or transiently transfected with PINK1 siRNA. In STOML2-high expression cells, the effect of lenvatinib on inhibiting colony formation (A) and migration (B) of HCC cells was weakened while the inhibitory effect of lenvatinib was restored in when CQ treated or siPINK1 transfected cells. (C–D) Silencing PINK1 with short interfering RNA in SMMC-7721-STOML2 and HCCLM3. **P<0.01; ***P<0.001.

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National Natural Science Foundation of China (CN) National Natural Science Foundation of China Natural Science Foundation of Shanghai Zhejiang Province Public Welfare Technology Application Research Project National Key Scientific Instrument and Equipment Development Projects of China

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    Journal of Hematology & Oncology

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    Keywords

    Stomatin-like protein 2 (STOML2)Hepatocellular carcinoma (HCC)PTEN-induced putative kinase 1 (PINK1)MitophagyLenvatinib

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