Additional file 5 of The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
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posted on 2023-09-30, 03:22 authored by Amanda L. Wright, Lyndsey M. Konen, Bruce G. Mockett, Gary P. Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P. Tan, Gordon A. Royle, Ian Clark, Steven Petrou, Wickliffe C. Abraham, Bryce VisselAdditional file 5: Sup Figure 5. ADAR2 downregulation. ADAR2 expression is downregulated as shown in immunoassays from (a) J20 mice and (b) 5xFAD mice as compared to WT littermates (t-test = 2.68, p < 0.028; n = 5/genotype; t-test = 2.95, p = 0.021; n’s: WT = 5 and 5xFAD = 4). B shows interpolated blots as well as example electropherograms (EPG) used for analysis. Each value represents the mean ± the SD. *p<0.05.
