Additional file 5: of Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma
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posted on 2019-06-17, 05:00 authored by Noah Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew Svalina, Lara Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael Quist, Kevin Matlock, Martin Goros, Brian Hernandez, Yee Doung, Khin Thway, Tomohide Tsukahara, Jun Nishio, Elaine Huang, Susan Airhart, Carol Bult, Regina Gandour-Edwards, Robert Maki, Robin Jones, Joel Michalek, Milan Milovancev, Souparno Ghosh, Ranadip Pal, Charles KellerFigure S5. PTIM models developed using secondary datasets. (A) Chemical screen + siRNA informed PTIM. Values in the center of PTIM blocks represent expected scaled sensitivity following inhibition of associated block targets. (B) Chemical screen + phosphoproteomics informed PTIM. The values within the target blocks indicate scaled drug sensitivity [16] when block targets are inhibited. (TIF 22272 kb)
