Additional file 5 of Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice

Additional file 5: Figure S5. Organizational abnormalities of N-cadherin expression in the cranial neural folds and NTD of p120fl/fl;Wnt1Cre mutant mice. IHC of p120ctn (a) and of N-cadherin (c) on a cranial neural tube of an E9.5 control embryo showed prominent coexpression. In an E9.5 (25–30 somites) mutant embryo, p120ctn was strongly ablated (b; asterisk, section artefact), whereas strong expression of N-cadherin was retained (d). In the latter situation, focal N-cadherin aggregation and a non-coherent exposed cell layer were visible (d, arrows), in contrast to the uniform N-cadherin expression and the closed cell layer facing the ventricular lumen in the control neural tube (c, arrowheads). Scale bar: 20 μm.