12943_2017_701_MOESM5_ESM.tif (9.66 MB)
Additional file 5: Figure S4. of Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
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posted on 2017-07-24, 05:00 authored by Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan, Qingyong MaThe effect of metfomin on AMPK/mTOR signaling. (A) Immunohistochemical staining of p-AMPK and p-mTOR in pancreatic tissues from KPC mice treated with vehicle or metformin. (B) Western blotting assays show the expression of p-AMPK, AMPK, p-mTOR, mTOR, p-P70S6K, and P70S6K in pancreatic tissues from KPC mice treated as indicated. (TIFF 9891 kb)
