Additional file 4 of miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling

Additional file 4: Figure S1. Wild-type and mutant SMAD4 3′UTR constructs. (Top) Wild-type miR-1323 binding site 1 in the SMAD4 3′UTR luciferase reporter construct (WT-SMAD4 3′UTR) and the engineered mutant miR-1323 binding site 1 in the SMAD4 3′UTR luciferase reporter construct (MUT-BMP4 3′UTR). (Bottom) Wild-type miR-1323 binding site 2 in the SMAD4 3′UTR luciferase reporter construct (WT-SMAD4 3′UTR) and the engineered mutant miR-1323 binding site 2 in the SMAD4 3′UTR luciferase reporter construct (MUT-BMP4 3′UTR).