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Additional file 4 of Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma
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posted on 2020-11-26, 05:30 authored by Shejuan An, Jeannie M. Camarillo, Tina Yi-Ting Huang, Daphne Li, Juliette A. Morris, Madeline A. Zoltek, Jin Qi, Mandana Behbahani, Madhuri Kambhampati, Neil L. Kelleher, Javad Nazarian, Paul M. Thomas, Amanda M. SaratsisAdditional file 4: S4. H3.3K27M, H3.1K27me3, and H3.3K27me3 peptide abundance in cell lines. Targeted mass spectroscopy reveals differences in H3.3K27M, H3.1K27me3, and H3.3K27me3 peptide abundance in pediatric glioma and adult glioma cells, and normal human astrocytes. Of note, loss of H3.1K27 and H3.3K27 trimethylation is observed in H3.3K27M cell lines.