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Additional file 4 of Exome-based investigation of the genetic basis of human pigmentary glaucoma
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posted on 2021-06-27, 03:16 authored by Carly van der Heide, Wes Goar, Kacie J. Meyer, Wallace L. M. Alward, Erin A. Boese, Nathan C. Sears, Ben R. Roos, Young H. Kwon, Adam P. DeLuca, Owen M. Siggs, Claudia Gonzaga-Jauregui, Val C. Sheffield, Kai Wang, Edwin M. Stone, Robert F. Mullins, Michael G. Anderson, Bao Jian Fan, Robert Ritch, Jamie E. Craig, Janey L. Wiggs, Todd E. Scheetz, John H. FingertAdditional file 4: Supplementary Figure 1. Principal components analysis of the PDS and control cohort from Iowa. The entire Iowa cohort of was investigated with principal components analysis of SNPs identified from exome sequences. The distribution of the first and second principal components (PC1 and PC2) are shown where the 200 PDS patients are each represented with red dots and the 361 controls are each represented with blue dots. PANEL A. Four individuals that are outliers for principal components 1 and 2 are shown with the green arrows. A tight cluster of the remaining 557 study subjects are located within a small red box. PANEL B. An exploded view of the red box in panel A showing the distribution of 557 members of the Iowa cohort with the 4 outliers removed.
