Additional file 4 of A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease

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posted on 2020-10-16, 03:31 authored by James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts

ML-SA1 rescues enlarged LAMP1 positive compartments from LITAF KO and FIG4 KO fibroblasts. Immunofluorescence showing LAMP1 and Cathepsin D labelling in control, LITAF KO and FIG4 KO fibroblasts without and with treatment with ML-SA1 (40μM, 36 h).

Funding

Wellcome Trust Medical Research Foundation H2020 European Research Council Newton Fund

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DOI - Is supplement to A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease

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Keywords

Charcot–Marie–Tooth Peripheral neuropathy LITAF Endosome Lysosome Phosphoinositide

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CC BY + CC0