Additional file 4: Figure S4. of TLR4-NOX2 axis regulates the phagocytosis and killing of Mycobacterium tuberculosis by macrophages

LPS upregulates ROS levels in peripheral blood mononuclear cells (PBMCs) from TB patients. PBMCs were isolated from patients with active tuberculosis and healthy volunteers. Age and gender factors were considered to match. In the supplementary experiments, 5 × 105/mL PBMCs from patient or health control were treated with or without 100 ng/mL LPS for 6 h, and ROS levels were measured using flow cytometry. The bar graph showed statistical difference of ROS levels (*; P < 0.05 compared to health control). (TIFF 203 kb)