13046_2019_1179_MOESM3_ESM.tif (4.76 MB)

Additional file 3: of MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia

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posted on 16.05.2019, 05:00 by Bing Liu, Hongye Ma, Qianqian Liu, Yang Xiao, Shimeng Pan, Huimin Zhou, Li Jia
Figure S3. Differential CD44 fucosylation and activity of Wnt/β-catenin pathway were determined. (A) LTL-CD44 level and CD44 level were higher in LSCs than that in non-LSCs of KG-1a cells. (B) LTL-CD44 level and CD44 level were higher in LSCs than that in non-LSCs of MOLM13 cells. (C) The activity of Wnt/β-catenin pathway was revealed enhanced through detecting key molecules expression in LSCs of KG-1a cells. (D) The activity of Wnt/β-catenin pathway was revealed enhanced through detecting key molecules expression in LSCs of MOLM13 cells. Data are means ± SD of three independent assays (*P < 0.05). (TIF 4873 kb)

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National Natural Science Foundation of China

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