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Additional file 3: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

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posted on 2019-05-29, 05:00 authored by Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng, Shiow-Lin Pan
Figure S3. ERK inhibition can downregulate EGFR expression. (A) AsPC-1 cells were treated with indicated concentrations of PD98059 for 24, 48, and 72 h. p-ERK and EGFR protein levels were determined. (B) AsPC-1 cells were transfected with scramble or ERK siRNA for 48 h to evaluate the protein expression of ERK and EGFR. Actin was loaded as an internal control. (TIF 440 kb)


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