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Additional file 3: Figure S3. of A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

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posted on 12.06.2017, 05:00 by Rustam Esanov, Gabriela Cabrera, Nadja Andrade, Tania Gendron, Robert Brown, Michael Benatar, Claes Wahlestedt, Christian Mueller, Zane Zeier
Linear regression analysis of the mean C9ORF72 promoter methylation percentile (as determined by bisulfite pyrosequencing) and glycine-proline dipeptide abundance (A). R square and p values for individual CpG dinucleotides are indicated (B). Quantitative PCR assessment of C9ORF72 expression in hypermethylated C9-BAC mice indicated by open shapes (17wks square, 30wks triangle, 36wks circle) and their age group counterparts (C), error bars represent SEM. (JPEG 530 kb)


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