Additional file 3: Figure S3. of A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

Linear regression analysis of the mean C9ORF72 promoter methylation percentile (as determined by bisulfite pyrosequencing) and glycine-proline dipeptide abundance (A). R square and p values for individual CpG dinucleotides are indicated (B). Quantitative PCR assessment of C9ORF72 expression in hypermethylated C9-BAC mice indicated by open shapes (17wks square, 30wks triangle, 36wks circle) and their age group counterparts (C), error bars represent SEM. (JPEG 530 kb)