Additional file 3: Figure S2. of Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

RAB3C overexpression increases exocytosis of colon cancer cells and promotes metastasis through IL-6 secretion. (A) The significant effect of RAB3C overexpressing cell-conditioned medium on the migration ability of parental colon cancer cells indicate that the metastasis-promoting role of RAB3C is exocytosis dependent. (B) Relative IL-6 activity in conditioned medium of CX-1 cells and SW48 cells with or without the exogenous RAB3C gene. The data were the average of three independent experiments and are presented as the mean ¹ SEM. The significance of the difference was analyzed using the nonparametric Mann-Whitney U test. (TIFF 28902 kb)