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Additional file 2 of Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes
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posted on 2020-06-08, 03:50 authored by Liqing Kang, Xiaowen Tang, Jian Zhang, Minghao Li, Nan Xu, Wei Qi, Jingwen Tan, Xiaoyan Lou, Zhou Yu, Juanjuan Sun, Zhenkun Wang, Haiping Dai, Jia Chen, Guoqing Lin, Depei Wu, Lei YuAdditional file 2: Figure S2. IL-6 knockdown in ssCART-19 cells have no effect on the IL-1 expression and secretion profile. IL-1α mRNA (A) and protein levels (B) in ssCART-19 cells and regular CART-19 cells after co-cultured with Raji. IL-1β mRNA (C) and protein levels (D) in ssCART-19 cells and regular CART-19 cells after co-cultured with Raji. Differences were assessed for significance using one-way ANOVA. Data are expressed as the mean + SD. NS, no significant difference, *p < 0.05.