Additional file 2: Fig. S2. The mRNA level of E-cadherin in A549 cells with or without E2 treatment was studied by q-PCR. After three independent experiments were completed, the results were quantitated, and statistical analysis was performed with a t test; *p < 0.05 (A). The level of E-cadherin in EGFRL858R-induced lung cancer mice including male and female mice was studied by IHC assay (B)