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Additional file 2 of Bortezomib potentiates antitumor activity of mitoxantrone through dampening Wnt/β-catenin signal pathway in prostate cancer cells

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posted on 14.10.2021, 03:27 by Ying Zhang, Qiuzi Liu, Wei Wei, Guoan Zhang, Siyuan Yan, Rongrong Dai, Ying Sun, Dubo Su, Shun Lv, Yong Xia, Jing Li, Changlin Li
Additional file 2 Fig. S2 Expression of β-Catenin target genes. A-D. LNCaP (A, C) and 22RV1 (B, D) cells were treated with vehicle, BZM (200 nM), MTX (1 μM) alone or combination (BZM, 100 nM; MTX, 0.5 μM) for 24 h. Real-time PCR assay of indicated genes expression. A, B. Relative mRNA levels of β-Catenin. C, D. Relative mRNA levels of MMP7 and Axin2. Data are presented as from three independent experiments and mean ± s.e.m. The asterisk indicates a significant difference compared to the vehicle control (one-way ANOVA, *p < 0.05, **p < 0.01).