Additional file 1: of Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents
posted on 2019-01-07, 05:00authored byRiccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria Pantaleo, Luigi Larocca
Figure S1. Microphotograph showing a SDH-deficient GIST (case 43). (a) Tumor consisted of sheets of epithelioid cells with eosinophilic cytoplasm (scale bar: 15 μm). (b) Tumor cells lack cytoplasmic SDHB granular positivity, retained in non-neoplastic cells (notice the cytoplasmic labeling of smooth muscle cells, both in gastric muscularis propria—top left—and in a blood vessel wall—center—, or of scattered tumor infiltrating leukocytes and plasma cells) (scale bar: 15 μm). (TIF 16742 kb)