posted on 2024-06-28, 03:39authored byEmely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall, Laura B. Duvall
Supplementary Material 1: Figure 1. Small-molecule NPYLR7 agonists do not affect meal palatability. (A) Percent of females feeding to repletion and (B) weight per female after feeding on the indicated meal used for testing in Miniport olfactometer experiments in Figure 3B. (C) Percent of females feeding to repletion and (D) weight per female after feeding on the indicated meal used for testing in live host assays in Figure 4. Data are shown as mean with standard deviation. n = 2–22 replicate cages, 60–150 females/cage. Females were weighed in groups of five to ensure reliable readings. Kruskal–Wallis with Dunn’s multiple comparisons to saline-fed group, ns P > 0.01, * P < 0.01, *** P < 0.0001. (PNG 321 KB)
Funding
Sanders Tri-Institutional Therapeutics Development Fund Howard Hughes Medical Institute National Center for Advancing Translational Sciences National Institute of General Medical Sciences The Arnold and Mabel Beckman Foundation The Pew Foundation Esther A. and Joseph Klingenstein Fund