Additional file 1 of Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells

Additional file 1: Fig. S1. Schematic of the double emulsion solvent evaporation method to formulate Ab@Tf-Cou6-PLGA NPs. The anti-BCR/ABL antibodies were mixed with chloroform containing PLGA and Cou6. The mixture was sonicated to obtain the first emulsion. Then, the first emulsion was mixed with 10 ml of PVA (1%) and sonicated to obtain the second emulsion. Furthermore, the chloroform was evaporated at room temperature to obtain the Ab@Cou6-PLGA NPs. The Ab@Tf-Cou6-PLGA NPs were synthesized after being modified with transferrin.