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Additional file 1: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis
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posted on 2018-04-10, 05:00 authored by Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Yasuhiro Shinkai, Yoshito Kumagai, Akihito Ishigami, Takayuki SumidaFigure S1. DBA/1 mice were immunized with pGPI. (a) The clinical score (mean Âą SEM) of pGIA (n = 11). (b) Sera were obtained once per week between days 0 and 28 from pGIA and control mice. The titers of anti-CCP antibodies were analyzed by ELISA (n = 12â18). Each symbol represents a single mouse, and the horizontal and vertical bars represent the mean and SEM values, respectively. *p < 0.05, **p < 0.01. (TIFF 120 kb)