Additional file 1 of AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
posted on 2025-01-11, 04:24authored byZhuan Zou, Songmu Pan, Changzheng Sun, Jiyong Wei, Yi Xu, Kaizhen Xiao, Jinmin Zhao, Ronghe Gu
Supplementary Material 1: Figure S1. Molecular docking of AM1241 with Keap1 and NEMO/IKKβ. (A) The detailed connection method between AM1241 and Keap1. (B) The detailed docking method between AM1241 and NEMO/IKKβ. AM1241 is brown, and the blue solid line represents the hydrogen bond distance. (C) Autodock-vina was used for semi-flexible docking and the obtained scores and interaction energy results are shown in the table
Funding
the Natural Science Foundation of Guangxi Province Nanning excellent young scientist program