Additional file 1: Figure S1. of Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas

Breeding of mouse lines and UV scheme used in this study. (a) Breeding crossings used. K14-Cretg/O I RxrαL2/L2 is also known as Rxrαep−/−. (b) Scheme for single neonatal UVB treatment of mice. (c) H&E stained section showing poorly differentiated melanoma with abnormally large nuclei compared to the normal range (inset). (TIFF 1999 kb)