Springer Nature
13287_2018_1107_MOESM13_ESM.tif (1.78 MB)

Additional file 13: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

Download (1.78 MB)
posted on 2019-01-11, 05:00 authored by Chen Kan, Na Ding, Jiazhao Yang, Zhenya Tan, Tammy McGuire, Haimei Lu, Keqin Zhang, Diana Berger, John Kessler, Lixin Kan
Figure S10. Working model of injury-induced MSC niche. Injury-induced local microenvironment (MSC niche) is composed of niche-dwelling progenitor/stem cells (including at least Tie2-cre, Gli1-creER and Glast-creERT labeled cells) and niche supportive cells (including mast cells, neurites, vasculature and macrophages). The formation of the MSC niche likely initiates the pathological osteogenic cascade, under the co-regulation of BMP and Hh signaling through feedback and non-cell autonomous mechanisms. (TIF 1825 kb)


National Natural Science Foundation of China