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Additional file 12: of Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma
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posted on 2019-06-17, 05:00 authored by Noah Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew Svalina, Lara Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael Quist, Kevin Matlock, Martin Goros, Brian Hernandez, Yee Doung, Khin Thway, Tomohide Tsukahara, Jun Nishio, Elaine Huang, Susan Airhart, Carol Bult, Regina Gandour-Edwards, Robert Maki, Robin Jones, Joel Michalek, Milan Milovancev, Souparno Ghosh, Ranadip Pal, Charles KellerFigure S12. Probabilistic Target Inhibition Map (PTIM) models from U23674 experimental rewiring data. Values in the center of PTIM blocks represent expected scaled sensitivity following inhibition of associated block targets. (A) Untreated initial culture PTIM. (B) Untreated secondaryculture PTIM. (C) OSI-906-treated rewire PTIM. (D) GDC-0941-treated rewire PTIM. (E) OSI-906â+âGDC-0941-treated rewire PTIM. (TIF 41768 kb)
