Molecular architecture of the human TRPC1/C5 heteromeric channel

The cryo-EM density maps and corresponding atomic coordinates for TRPC1/C5, TRPC5 Class 1, TRPC5 Class 2, TRPC5 with EA and riluzole Class 1, and TRPC5 with EA and riluzole Class 2 have been deposited in the Electron Microscopy Data Bank (EMDB) and the Protein Data Bank (PDB) under EMDB accession codes EMD-62343 [https://www.ebi.ac.uk/emdb/EMD-62343] (TRPC1/C5), EMD-62344 [https://www.ebi.ac.uk/emdb/EMD-62344] (TRPC5 Class 1), EMD-62345 [https://www.ebi.ac.uk/emdb/EMD-62345] (TRPC5 Class 2), EMD-63533 [https://www.ebi.ac.uk/emdb/EMD-62533] (TRPC5 with EA and riluzole Class 1), and EMD-63534 [https://www.ebi.ac.uk/emdb/EMD-62534] (TRPC5 with EA and riluzole Class 2), and under PDB accession codes 9KHI [http://doi.org/10.2210/pdb9KHI/pdb] (TRPC1/C5), 9KHJ [http://doi.org/10.2210/pdb9KHJ/pdb] (TRPC5 Class 1), 9KHK [http://doi.org/10.2210/pdb9KHK/pdb] (TRPC5 Class 2), 9LZY [http://doi.org/10.2210/pdb9LZY/pdb] (TRPC5 with EA and riluzole Class 1), and 9LZZ [http://doi.org/10.2210/pdb9LZZ/pdb] (TRPC5 with EA and riluzole Class 2), respectively.