Metadata record for the manuscript: Unique gap junction- and cofilin-dependent cellular protrusions mediate cancer cell migration by tethering to osteogenic cells

dataset

posted on 2020-09-02, 08:57 authored by Aaron M. Muscarella, Wei Dai, Patrick G. Mitchell, Weijie Zhang, Hai Wang, Luyu Jia, Fabio Stossi, Michael A. Mancini, Wah Chiu, Xiang H.-F. Zhang

This metadata record provides details of the data supporting the claims of the related manuscript: “Unique gap junction- and cofilin-dependent cellular protrusions mediate cancer cell migration by tethering to osteogenic cells”. The data consist of 10 files.

The related study investigated migration and invasion of metastatic cancer cells and discovered an alternative “migration-by-tethering” mechanism through which cancer cells gain the momentum to migrate by adhering to mesenchymal stem cells or osteoblasts.

The data files are as follows:

- FlowCytometryParameters.wsp - Underlying Figure 4 e in the related manuscript.

- Incucyte Timelapse Transwell Data.txt - Underlying Supplementary Figure 1 e.

- Muscarella et al Final Submission Raw Data.xlsx - Underlying all figures in the related manuscript and all supplementary figures. This file contains many tabs labelled by which figure they relate to.

- Muscarella et al Revision Supplemental Figures.pdf - Containing all supplementary figures and Supplementary - Table 1.mp4 - See the Results section of the related manuscript for details.

- Supplementary Video 1.mp4 - See the Results section of the related manuscript for details.

- Supplementary Video 2.mp4 - See the Results section of the related manuscript for details.

- Supplementary Video 3.avi - See the Results section of the related manuscript for details.

- Supplementary Video 4.mp4 - See the Results section of the related manuscript for details.

- Supplementary Video 5.mp4 - See the Results section of the related manuscript for details.

- Supplementary Video 6.mp4 - See the Results section of the related manuscript for details.

Funding

Targeting Breast Cancer Micrometastases: To Eliminate the Seeds of Evil

Congressionally Directed Medical Research Programs

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NCI CA183878

NCI CA221946

Breast Cancer Research Foundation

McNair Medical Institute

3 D Electron Microscopy of Macromolecules

National Institute of General Medical Sciences

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NIH (DK56338, and CA125123)

CPRIT (RP150578, RP170719)

The Dan L. Duncan Comprehensive Cancer Center

John S. Dunn Gulf Coast Consortium for Chemical Genomics

CPRIT-RP180672

NIH RR024574

History

Research Data Support

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