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Metadata record for the manuscript: Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast

dataset

posted on 2020-08-25, 11:27 authored by Clara Bodelon, Hannah Oh, Andriy Derkach, Joshua N. Sampson, Brian L. Sprague, Pamela Vacek, Donald L. Weaver, Shaoqi Fan, Maya Palakal, Daphne Papathomas, Jackie Xiang, Deesha A. Patel, Laura Linville, Susan E. Clare, Daniel W. Visscher, Carolyn Mies, Stephen M. Hewitt, Louise A. Brinton, Anna Maria V. Storniolo, Chunyan He, Stephen J. Chanock, Montserrat Garcia-Closas, Gretchen L. Gierach, Jonine D. Figueroa

Summary

The data described in this metadata record underlie the findings of the related manuscript, which evaluated whether a recently developed polygenic risk score (PRS) based on 313-common variants for breast cancer prediction is related to terminal duct lobular unit (TDLU) involution in the background, normal breast tissue, as this could provide mechanistic clues on the genetic predisposition to breast cancer.

Data access

The PRS data are in the R file ‘BC.impute.313.Rdata’. The BREAST Stamp Project data are not publicly available because the informed consent signed by the patients did not include public data sharing. However, these data are available through the Susan G. Komen Tissue Bank (KTB)’s virtual repository (http://virtualtissuebank.iu.edu). To request these data, contact Dr. Gretchen Gierach (gierachg@mail.nih.gov). The phenotype and polygenic risk scores are available from the dbGaP repository under the following accession ID: https://identifiers.org/dbgap:phs002062.v1.p1

Data contact details

Dr. Gretchen Gierach
National Cancer Institute
Division of Cancer Epidemiology and Genetics
Bethesda, MD 20892
United States
gierachg@mail.nih.gov

Name of Institutional Review Board or ethics committee that approved the study

Approval for this study was obtained from the Indiana University Institutional Review Board (IRB) and the National Institutes of Health Office of Human Subjects Research (NIH OHSR #4508).

Funding

This research was supported by the Intramural Research Program of the National Cancer Institute, National Institutes of Health.

History

Research Data Support

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