Metadata record for the manuscript: Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer
dataset
posted on 2021-01-26, 10:39 authored by Dobrin Draganov, Zhen Han, Aamir Rana, Nitasha Bennett, Darrell J. Irvine, Peter P. Lee<p><b>Summary</b></p>
<p>This
metadata record provides details of the data supporting the claims of the
related manuscript: “Ivermectin converts cold tumors hot
and synergies with immune checkpoint blockade for treatment of breast cancer ”.</p>
<p>The
related study shows that treatment with the FDA-approved anti-parasitic drug
ivermectin induces immunogenic cancer cell death (ICD) and robust T cell
infiltration into breast tumours.</p>
<p> </p>
<p>Type of data:
tumour size measurements, flow cytometry, histology </p>
<p>Subject of
data: 4T1 cell line, BALB/c (<i>Mus musculus</i>)</p>
<p> </p>
<p><b>Data
access</b></p>
<p>The flow
cytometry data (fluorescence-activated cell sorting--FACS) are available upon request from the corresponding author.</p>
<p>Other data
generated as part of the related study are tumour size measurements and
histology. These are available upon request from the corresponding author.</p>
<p> </p>
<p><b>Corresponding author(s) for this study</b></p>
<p>Peter
P. Lee, M.D., Dept. of Immuno-Oncology, City of Hope and Beckman Research
Institute, Beckman Center, room 5117, 1500 East Duarte Road, Duarte, CA 91010.
Email: plee@coh.org.</p>
<p><br>
<b>Study approval </b></p>
<p>All
procedures were performed under approval from City of Hope’s Animal Care and
Use Committee.</p>
