top10000snp_Lin.txt (731.93 kB)
Genome-wide association study summary data of 10,000 single nucleotide polymorphisms from a squamous cell carcinoma meta-analysis
dataset
posted on 2020-02-18, 17:32 authored by Kavita Y. Sarin, Yuan Lin, Roxana Daneshjou, Andrey Ziyatdinov, Gudmar Thorleifsson, Adam Rubin, Luba M. Pardo, Wenting Wu, Paul Khavari, Andre Uitterlinden, Tamar Nijsten, Amanda E. Toland, Jon H. Olafsson, Bardur Sigurgeirsson, Kristin Thorisdottir, Eric Jorgensen, Alice Whitemore, Peter Kraft, 23andMe Research Team, Simon N. Stacey, Kari Stefansson, Maryam M. Asgari, Jiali HanThis dataset consists of a single spreadsheet in .txt format.
The data are genome-wide association study (GWAS) data relating to 10,000 single nucleotide polymorphisms (SNPs) from a squamous cell carcinoma (SCC) meta-analysis.
The related publication presents a cutaneous SCC meta-analysis, representing 6 international cohorts and totalling 19,149 SCC cases and 680,049 controls. 8 novel loci associated with cutaneous SCC are discovered, all (14) previously associated loci are confirmed, and fine mapping of causal variants is performed. The novel SNPs occur within skin specific regulatory elements and implicate loci involved in cancer development, immune regulation, and keratinocyte differentiation in SCC susceptibility.
