Additional file 7 of Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia

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posted on 2024-08-14, 12:33 authored by Kimberly C. Olney, Camila de Ávila, Kennedi T. Todd, Lauren E. Tallant, J. Hudson Barnett, Katelin A. Gibson, Piyush Hota, Adithya Shyamala Pandiane, Pinar Cay Durgun, Michael Serhan, Ran Wang, Mary Laura Lind, Erica Forzani, Naomi M. Gades, Leslie F. Thomas, John D. Fryer

Additional file 7: Table S6. Differentially expressed genes between mouse and pig brains following LPS challenge reveal oppositely expressed genes between species. Inference to determine if genes are consistently up or downregulated among the pig and mouse species challenged with LPS compared to saline controls. To compare which differentially expressed genes are shared or unique between pig and mouse, the gene ids were first converted to human gene symbols following gprofiler2 gorth function (see Materials and methods)

Funding

ARCS Spetzler Scholar Mayo Clinic ASU Team Science Grant Mayo Foundation The Ben-Dov Luminescence Foundation The Ed and Ethel Moore Alzheimer’s Disease Research Program of Florida Department of Health (6AZ06) The Rotary Coins for Alzheimer’s Research Trust Fund CureAlz Foundation The Goodman Family Foundation NIH

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Immunology

Keywords

Systemic inflammation Sepsis Septic Shock Lipopolysaccharide LPS Infection Organ dysfunction Acute kidney injury Pig model Porcine model Bulk RNA-seq Brain impairment Transcriptome Immune system Immune regulation

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