Additional file 6: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

Huntington-specific differentially expressed genes. Genes (with Ensembl Gene ID) found to be DE in at least one time point (adjusted P-value < 0.1, moderated F-test) compared to the pre-induction state in the HD samples after correction for effects observed in the control samples. Genes are identified by Ensembl and Entrez Gene ID and gene symbol in the first three columns. The (adjusted) overall P-value gives the (adjusted) P-value for a gene to be significantly DE in at least one time point measured in the experiment. Each gene was placed in a cluster as determined by the CLICK algorithm. FC shows the fold change in expression compared to the pre-induction state with (adjusted) P-value listing the (adjusted) P-value resulting from significance testing of differential expression of the gene at that time point. Nrf2-regulated genes and genes involved in dopamine biosynthesis identified by van Roon-Mom et al. [55] are highlighted in yellow and blue, respectively. (XLSX 891 kb)