Additional file 5: Figure S4. of
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
posted on 2016-03-23, 05:00authored byJody Phelan, Francesc Coll, Ruth McNerney, David Ascher, Douglas Pires, Nick Furnham, Nele Coeck, Grant Hill-Cawthorne, Mridul Nair, Kim Mallard, Andrew Ramsay, Susana Campino, Martin Hibberd, Arnab Pain, Leen Rigouts, Taane Clark
The relationship between the total number of non-synonymous SNPs in candidate loci and the MIC values. The size of the circle represents the number of isolates. a) Ethambutol (embB, embA, embA promoter, embC, embR and ubiA). b) Streptomycin (rpsL, rrs). The size of the circles is proportional to the frequency. The MIC values tend to increase with the number of non-synonymous mutations (ethambutol: rho = 0.24, slope = 0.29, p = 0.003; streptomycin: rho = 0.48, slope = 3.59, p = 1.65 × 10-8). The horizontal blue lines refer to the resistance cut-offs. (ZIP 92 kb)
Funding
Biotechnology and Biological Sciences Research Council