13073_2020_799_MOESM4_ESM.xlsx (1.55 MB)

Additional file 4 of Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

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posted on 2020-11-21, 04:41 authored by Juha Mehtonen, Susanna Teppo, Mari Lahnalampi, Aleksi Kokko, Riina Kaukonen, Laura Oksa, Maria Bouvy-Liivrand, Alena Malyukova, Artturi Mäkinen, Saara Laukkanen, Petri I. Mäkinen, Samuli Rounioja, Pekka Ruusuvuori, Olle Sangfelt, Riikka Lund, Tapio Lönnberg, Olli Lohi, Merja Heinäniemi

Additional file 4: Table S3. Supporting information related to scDD analysis. Cluster membership is indicated for significant genes from leukemic vs. pro-B comparison (against adult and pediatric BM cells), and from drug vs. ctrl (DMSO) cells in the ETS-inhibition experiments carried out in E/R+ REH cells. Includes statistical summaries for cell state comparisons related to Figs. 2 and 5.

Funding

Finnish Hematology Association Academy of Finland Lasten Syöpäsäätiö Väreen Emil Aaltosen Säätiö Syöpäsäätiö Jane ja Aatos Erkon Säätiö Sigrid Juséliuksen Säätiö Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital Itä-Suomen Yliopisto ERA PerMed

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Keywords

Cell differentiation Leukemia Gene regulation Single cell genomics

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