13073_2021_967_MOESM3_ESM.xlsx (24.73 kB)
Additional file 3 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
dataset
posted on 2021-10-11, 03:14 authored by Marcus M. Soliai, Atsushi Kato, Britney A. Helling, Catherine T. Stanhope, James E. Norton, Katherine A. Naughton, Aiko I. Klinger, Emma E. Thompson, Selene M. Clay, Soyeon Kim, Juan C. Celedón, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Robert C. Kern, Bruce K. Tan, Robert P. Schleimer, Dan L. Nicolae, Jayant M. Pinto, Carole OberAdditional file 3: Gene expression PCA results for unadjusted (Gx Unadjusted) and adjusted (Gx Adjusted) data. P-values are shown for correlations for the first 10 PCs with each covariate.
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National Institutes of Health Ernest S. Bazley Charitable Fund
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study provides evidencedna methylation dataepigenetic response mechanismsadult onset asthmamodulate genetic effects21 asthma locuswide association studiesused mendelian randomizationtreated upper aecsassociated gwas snpsspecific genetic mechanismspecific functional annotationschildhood onset asthmaasthma colocalized locimapped cis expressionaec molecular qtlsasthma risk variantswide geneticchildhood onsetfunctional effectsresults asthmavariants associatedtslp locusgene expressionethnic gwasepigenetic responsesepidemiological studiesspecific informationvariants discoveredtreatment conditionpromoting pathogenmediated transcriptionalincluding qtlsimmune diseasesidentified thousandshealthy participantsenvironmental factorsculture modelcomplex diseasescell typesbayesian testassess transcriptionalallergic diseaseaec qtls38 ).
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