Additional file 3 of Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
dataset
posted on 2024-08-13, 16:25 authored by Eleonora Cesari, Alessandra Ciucci, Marco Pieraccioli, Cinzia Caggiano, Camilla Nero, Davide Bonvissuto, Francesca Sillano, Marianna Buttarelli, Alessia Piermattei, Matteo Loverro, Floriana Camarda, Viviana Greco, Maria De Bonis, Angelo Minucci, Daniela Gallo, Andrea Urbani, Giuseppe Vizzielli, Giovanni Scambia, Claudio SetteAdditional file 3. RNA-seq datasets: regulated genes and pattern exons.
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Associazione Italiana per la Ricerca sul Cancro Ministero della Salute
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quantitative pcr analysespromising therapeutic targetspotential therapeutic vulnerabilitiescancer relevant genesexerted synergic effectsclinically relevant drugshgsoc pdo viability13 inhibitor thz53113 inhibition enhances13 targetsviability assayspotential synergycdk13 genes13 inhibitionwide spectrumwide effectstargeted approachesstudy indicatessingle agentrna sequencingpoorly knownpathways regulatedpartly duelimited availabilityincluding hgsocimpaired splicinghuman cancershighly lethalhgsoc cellsdual inhibitionderived organoidscombined treatmentchemotherapy resistanceapproved drugs
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