40478_2022_1387_MOESM3_ESM.xlsx (874.53 kB)
Additional file 3 of Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia
datasetposted on 2022-07-08, 07:22 authored by Suzanne S. M. Miedema, Merel O. Mol, Frank T. W. Koopmans, David C. Hondius, Pim van Nierop, Kevin Menden, Christina F. de Veij Mestdagh, Jeroen van Rooij, Andrea B. Ganz, Iryna Paliukhovich, Shamiram Melhem, Ka Wan Li, Henne Holstege, Patrizia Rizzu, Ronald E. van Kesteren, John C. van Swieten, Peter Heutink, August B. Smit
Additional file 3 Lists of unique proteins detected and quantified within frontal and temporal cortical tissues for the RiMOD-FTD genetic subtypes. Proteins were selected using quality filtering on peptide level (q ≤10-3 in at least 50% of samples per group, i.e. NDC or FTD). For every protein, the raw fold change, raw p-value, multiple comparison corrected q-value, and effect size (d) are given for the statistical comparison between NDC and FTD subtype. In addition, columns are included which note whether a protein has passed statistical testing (either p < 0.05 or q < 0.05). Furthermore, the differential expression of several well-known neurodegeneration (ND)-related proteins in frontal cortical FTD-GRN vs NDC and temporal cortical FTD-MAPT vs NDC are highlighted. -; not detected within study cohort.