Additional file 2 of Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
dataset
posted on 2022-10-21, 03:23 authored by Nadeem Shaikh, Alice Mazzagatti, Simone De Angelis, Sarah C. Johnson, Bjorn Bakker, Diana C. J. Spierings, René Wardenaar, Eleni Maniati, Jun Wang, Michael A. Boemo, Floris Foijer, Sarah E. McClellandAdditional file 2. Contains CNAs for RPE1 after treatment with DMSO, Aphidicolin or siRNA.
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Pancreatic Cancer Research Fund Cancer Research UK (GB) KWF Kankerbestrijding AstraZeneca Marie Curie Medical Research Council Isaac Newton Trust
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one cell cyclecoupling cell typecommon fragile sitescausative large genesfuel chromosomal instabilityacute genomic consequencesrpe1 epithelial cellsreplication stress leadinduced replication stressdifferent genomic regionscancer chromosomal instabilitygenomic instabilityreplication stresstransformed cellsdna replicationdifferent inducerschromosome regionsspecific analysissmall subsetrecurrent chromosomeproviding insightsmultiple typesmolecular mechanismsmicronuclei containingmajor driverlatter confinedgene expressionfully exploredexact causesdiploid nonchromosome 7chromosome 1bj fibroblasts
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