Additional file 2 of Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach

Additional file 2: Table S1.  A list of 56 genes and the associated medical conditions recommended by ACMG for return of results. Table S2. The full list of the extracted PheCodes and the corresponding prevalences among the 15,181 individuals analyzed in the study. Table S3. The 37 PheCodes of psychiatric disorders with at least 75 cases selected for burden analysis. Table S4. Pairwise phenotypic correlations between the 37 psychiatric phenotypes. Table S5. Pairwise phenotypic correlations between the 37 psychiatric phenotypes and all 966 phenotypes with at least 75 cases. Table S6. PheWAS results of rare variation and psychiatric disorders: ACMG-56 genes. Table S7. PheWAS results of rare variation and psychiatric disorders: CACNA1C. Table S8. PheWAS results of rare variation and psychiatric disorders: TCF4. Table S9. PheWAS of rare variation and psychiatric disorders: interaction with age. Table S10. PheWAS of rare variation and psychiatric disorders: interaction with sex. Table S11. PheWAS of rare variation and psychiatric disorders: combining variation across 58 genes by functional annotation. Table S12. Gene Ontology analysis of the 58 genes: biological process. Table S13. Gene Ontology analysis of the 58 genes: cellular component. Table S14. Gene Ontology analysis of the 58 genes: molecular function.  Table S15. PheWAS of rare variation and psychiatric disorders: 34 genes from the top GO term of biological process. Table S16. PheWAS of rare variation and psychiatric disorders: 16 genes from the top GO term of cellular component. Table S17. PheWAS of rare variation and psychiatric disorders: 25 genes from the top GO term of molecular function. Table S18. Phenotypic comparison between eMERGE and UKB-GeneBass. Table S19. PheWAS results of rare variation and psychiatric disorders in UKB-GeneBass. Table S20. Suggested gene associations in eMERGE (Table 1) vs. in UKB-GeneBass