13059_2022_2787_MOESM2_ESM.xlsx (383.65 kB)
Additional file 2 of Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
dataset
posted on 2022-10-18, 03:24 authored by Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox, Duncan SproulAdditional file 2: Supplementary tables Table S1-7.
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cancer research uk medical research council
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using snp datatwo independent groupslocal sequence polymorphismslocal dna sequencecell type proportionsepigenetic mark associatedcpgs reinforce maintenancepredominantly lose methylationstatistically predict agecpg dense regionsassociated epigenetic changesassociated methylation changes600 individuals agedpeople agedindividual cpgs895 cpgsmethylation trajectoriesmethylation patternsepigenetic clocksyounger individualsprogram steadyparticularly proneinfluences agehuman diseasegene promotersfactors responsibleespecially apparentaltered ratesaging inferredage occur
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