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Additional file 2 of Limited evidence for blood eQTLs in human sexual dimorphism

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posted on 2022-08-12, 06:29 authored by Eleonora Porcu, Annique Claringbould, Antoine Weihs, Kaido Lepik, Tom G. Richardson, Uwe Völker, Federico A. Santoni, Alexander Teumer, Lude Franke, Alexandre Reymond, Zoltán Kutalik
Additional file 2: Table S1. Sex-specific eQTLs. Table S2. Summary statistics for eQTLs in binding sites for estrogen receptor genes. Table S3. Gene level summary statistics. Table S4. Wilcoxon test P-values for mean sex differences in cellular composition. Table S5. Wilcoxon test P-values for mean sex differences in principal components. Table S6. Levene test P-values for mean sex differences before and after correcting for principal components. Table S7. BIOS results for the sex-biased eQTLs found in Yao et al [PMID: 24242183]. Table S8. BIOS results for the sex-biased eQTLs found in Kukurba et al [PMID: 27197214]. Table S9. Replication analyses results - SHIP-Trend cohort. Table S10. PheWAS for top sex-specific eQTLs. Table S11. Independent SNPs associated with WHR. Table S12. Independent SNPs associated with testosterone. Table S13. Sex-stratified TWMR results for testosterone. Table S14. Sex-stratified TWMR results for WHR. Table S15. Sex specific causal genes for WHR and testosterone.

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Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung Horizon 2020 Bundesministerium für Bildung und Forschung

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    wide mendelian randomizationwide association studywide association studiesfound 18 genesfdr 5 %).effect sizes showedcompensatory effects mayassociated snps suggestssexually dimorphic traits700 traits unraveledseq eqtl datamany diseases differsperformed power analysisspecific genetic effects18 top sexspecific causal effectsbiased causal effectspecific trait associationsbiased trait associationsbiased traitcomplex traitsspecific transcriptomegenetic underpinningcomplex diseasesbiased cisspecific eqtlsperformed sexperformed separatelycombined associationsgwas databiased eqtlswhole bloodvice versauk biobanktestosterone levelssignificant sexsexual dimorphismsamples wouldresults suggestreported enrichmentpublished genomepotential rolepoorly understoodpart causedobserve sexlimited evidencehip ratiogene expressiondetectable sexcombined sexbios consortium

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