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Additional file 2 of Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa

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posted on 2022-09-04, 03:16 authored by Anne M. van der Does, Rashad M. Mahbub, Dennis K. Ninaber, Senani N. H. Rathnayake, Wim Timens, Maarten van den Berge, Hananeh Aliee, Fabian J. Theis, Martijn C. Nawijn, Pieter S. Hiemstra, Alen Faiz
Additional file 2. List of differentially expressed genes and associated pathways after cigarette smoke exposure compared to Air.

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    removing dysfunctional mitochondriae ., nrf2bronchial epithelial cellsairway epithelial cellscs ), littleresults provide validationknown detrimental effectscurrent study mirroredimmediate early genesearly transcriptomic changesearly transcriptional responses24 h hereaftervivo human studiespbec gene expressionhuman cs studiesacute cs exposurevivo studiestranscriptomic responses24 hciliated cellshigher expressionassociated geneswhole csearly stages4 hxenobiotic metabolismwhereas prknvitro modeltranscriptome dynamicsstudy aimssignificantly increasedsignificantly changedsignificant overlappbec culturesoxidative stressinhaled toxicantsinflammatory pathwaysfindings showdata retrievedcigarette smokechronic smokersbulk rnaahr ).additionally compared

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