12964_2020_523_MOESM2_ESM.zip (23.9 MB)
Additional file 2 of Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis
dataset
posted on 2020-05-05, 03:56 authored by Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv, Hua-Ping LiangAdditional file 1: Figure S1. Confirmation of transfections. Figure S2. Relative expression levels of inflammatory factors in overactivated macrophages. Figure S3. The inhibitory effects of Rhapontigenin on LPS-induced TNF-α and IL-6 secretion in PMs. Figure S4. Validation of the NF-κB signalling pathway and different MAPK signalling pathways in LPS-stimulated CYP1A1/RAW and NC/RAW. Figure S5. The levels of 12(S)-HETE in PLFs from E.coli- and CLP-induced septic mice. Figure S6. Detection of lentivirus infection rate in PMs. Figure S7. The regulation of CYP1A1-JNK-AP-1 axis in septic mice. Figure S8. Platelet count in PLFs from CYP1A1-overexpressed macrophages transferred septic mice. Figure S9. CYP1A1 is involved in phagocytosis of bacteria in macrophages during sepsis.