12943_2023_1753_MOESM1_ESM.zip (4.84 MB)
Additional file 1 of Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination
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posted on 2023-04-13, 16:14 authored by Hyunbin D. Huh, Yujin Sub, Jongwook Oh, Ye Eun Kim, Ju Young Lee, Hwa-Ryeon Kim, Soyeon Lee, Hannah Lee, Sehyung Pak, Sebastian E. Amos, Danielle Vahala, Jae Hyung Park, Ji Eun Shin, So Yeon Park, Han Sang Kim, Young Hoon Roh, Han-Woong Lee, Kun-Liang Guan, Yu Suk Choi, Joon Jeong, Junjeong Choi, Jae-Seok Roe, Heon Yung Gee, Hyun Woo ParkAdditional file 1: Movie S1. Induction and reversibility of AST in HEK293A-ASTTetR cells. Video 1. Video of HEK293A-ASTTetR cell proliferation in normal culture condition. Video 2. Video of HEK293A-ASTTetR cell proliferation after doxycycline treatment. Video 3. Video of HEK293A-ASTTetR cell proliferation after doxycycline removal.
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upregulate globin genessuppress global integrinreprograms anchorage dependencyreprogramming anchorage dependencyreprogram anchorage dependencyprevent oxidative stresscell rna sequencingbiological phenomenon referredanalyzed blood cellacquire anoikis resistancesolid tumor cellscirculating tumor cellsprimary tumor growthde novo metastasisconfer metastatic traitsselected key adherentreprograms adherent cellsadherent cells 1defined hematopoietic factorsmetastatic dissemination remainsadherent cellssuspension cellsprimary tumorsmetastatic tumorsmetastatic spreadblock metastasisvivo assaystissue stainingtead inhibitionsuspension transitionspecific transcriptsspecialized mechanismshrna knockdownreversible mannerrelated deathprolong survivalpharmacological inhibitionpharmacological blockadepaired samplesmouse modelslineage differentiationgene editingfunction experimentsforemost causefindings expanddirectly arisecritical rolescritical area
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