12014_2022_9354_MOESM1_ESM.xlsx (29 kB)

Additional file 1 of Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers

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posted on 2022-05-15, 04:26 authored by Sophia Weiner, Mathias Sauer, Pieter Jelle Visser, Betty M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg, Johan Gobom

Additional file 1. List of complete GO-terms relating to both significantly increased and decreased proteins (clinical AD vs. control) in EMIF-AD. Description of data: GO biological process terms were generated with the PANTHER statistical overrepresentation test. For significantly increased proteins, an FDR-correction was performed.

Funding

EU/EFPIA Innovative Medicines Initiative Joint Undertaking ZonMw Swedish Research Council Alzheimer's Drug Discovery Foundation Swedish Alzheimer Foundation Hjärnfonden ALF-agreement European Union Joint Program for Neurodegenerative Disorders National Institutes of Health Alzheimer’s Association 2021 Zenith Award Stiftelsen för Gamla Tjänarinnor European Research Council Swedish State Support for Clinical Research Alzheimer Drug Discovery Foundation AD Strategic Fund and the Alzheimer's Association Olav Thon Stiftelsen Familjen Erling-Perssons Stiftelse MIRIADE UK Dementia Research Institute at UCL Alzheimerfonden Gun och Bertil Stohnes Stiftelse Åhléns-stiftelsen University of Gothenburg

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Keywords

Tandem mass tag Cerebrospinal fluid Normalization Alzheimer’s disease Biomarkers Sample preparation Labeling efficiency Mass spectrometry

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